Diazepam antidote10/8/2023 ![]() Neurologic – confusion, dysarthria, nystagmus, lethargy, ataxia, areflexia, hypotonia, seizure.Calculate the maximum possible dose per kg of each drug.If possible, determine the exact name and tablet strength. ![]() Always assume maximum number of missing/unaccounted tablets have been ingested.Risk assessment Red flag features in Red History Diazepam is excreted mainly (about 70%) unchanged in the urine.Īll children with deliberate self-poisoning or significant accidental ingestion, especially younger children and toddlers.Īny child whose developmental age is inconsistent with accidental poisoning as non-accidental poisoning should be considered.An exception to this is Oxazepam, temazepam, and lorazepam which are directly conjugated.Drugs that interact with CYP enzymes may prolong the half-lives of most Benzodiazepines They are rapidly absorbed in the gastrointestinal tract, with peak plasma concentrations occurring 30 to 90 minutes after ingestion.Short-acting (half-life 24 h) eg Diazepam, these generally have pharmacologically active metabolites, accumulate in tissues after multiple doses, and demonstrate impaired clearance in children with liver disease.Benzodiazepines can be short, intermediate or long acting:.Sedation can be prolonged and last up to 36 hours. ![]()
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